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Description
CNTF Protein, MouseProduct Specification Species Mouse Synonyms Ciliary neurotrophic factor Accession P51642 Amino Acid Sequence Ala2 Met198 Expression System E. coli Molecular Weight 23kDa Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer 1xPBS, 2mM TCEP, pH 7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation. Stability &
Product Specification
| Species | Mouse |
| Synonyms | Ciliary neurotrophic factor |
| Accession | P51642 |
| Amino Acid Sequence | Ala2-Met198 |
| Expression System | E.coli |
| Molecular Weight | 23kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 1xPBS, 2mM TCEP, pH 7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Prog Retin Eye Res. 2012 Mar;31(2):136-51.Epub 2011 Dec 10. Eur Cytokine Netw. 2004 Jul-Sep;15(3):255-62. |
Background
Ciliary neurotrophic factor (CNTF) is one of the most studied neurotrophic factors for neuroprotection of the retina. It is a neuroprotective cytokine initially identified in chick embryo. It has been evaluated for the treatment of neurodegenerative diseases. CNTF also acts on non-neuronal cells such as oligodendrocytes, astrocytes, adipocytes and skeletal muscles cells.
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4.7 ★★★★★
Based on 2372 reviews
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Product Reviews
★★★★★ 5
Recommended by my breeder
Size: Small, Style: Wishbone/Dental
Purchased these two small sized Benebones for my puppy Springer Spaniel. It’s one of her favorite toys and it is well used and well worn. Replaced these with the medium size recently as she’s almost full grown now.
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Reviewed in the United States on June 9, 2026
★★★★★ 5
Adorable & Tough Rose Toy Perfect for Aggressive Chewers 🌹🐶
Color: Light Pink, Pattern Name: Roses, Color: Light Pink, Pattern Name: Roses
I bought this rose-shaped rubber toy for my dog and I’m honestly so impressed! The pink and green design is super cute and unique it really stands out from typical dog toys.
My dog is a pretty aggressive chewer, and this toy has held up really well. The rubber feels durable and strong, but still has enough flexibility to keep him interested and engaged. He absolutely loves playing with it and carries it around everywhere.
What I love most is that the textured rose design actually helps clean his teeth while he chews, which is a huge bonus. It’s like playtime and dental care in one!
If you have a strong chewer and want something functional but also aesthetically cute, this is a great choice. Definitely a new favorite in our house 🐾💗
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Reviewed in the United States on March 20, 2026
★★★★★ 5
Keep repurchasing
Color: Red, Pattern Name: Roses, Color: Red, Pattern Name: Roses
I bought these as a cute Valentine’s Day present for my dog. He typically destroys any toy within 10 minutes of giving it to him. This rose lasts months and it’s his favorite. He could chew this toy for hours. Every couple of months he’ll get a small chunk of the stem off but the rest of the rose stays intact. He’s good about dropping and leaving the chunk he rips off but I’d just keep a cautious eye on your dog if you notice a piece is starting to break away. (Side note: when a piece does start breaking off, my husband and I both struggle and typically can’t rip it off) We let him play with it until it’s just the flower and then throw it away and repurchase.
He also loves to play fetch with it. It’s not super bouncy but does have a little bit of a bounce if thrown on a hard ground. All we have to say is “Opie where’s your rose?” He goes running to his toy box and acts as a claw machine to get his rose specifically.
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Reviewed in the United States on September 30, 2023
★★★★★ 5
Amazing
Okay, our pups Belle 4 years (Lab and ?) and Chomp 1year old (Blue Nose Pit) could never keep a chew toy for more than an hour or two. Everything we bought them and everything in the Bark Box 📦 we ordered for them would be destroyed immediately.
I felt so bad, they were so excited to get these toys only to have them taken away so they didn't choke to death. I used to tell my hubby that I was going to send a challenge letter to various toy manufacturers daring them to make a chew toy that could contend with my "Aggressive Chewers".
Well, low and behold, I purchased this chew toy and after daily continous chewing and playing it is still in one piece, beat up, but in one piece. My Pit, Chomp, chews on this ALL THE TIME and it is in one piece. Bravo, your company has produced the best by far chew toy for, as you call them, "Aggressive Chewers".
Thank you so much.
Bill and Teri Rockenstein.
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Reviewed in the United States on March 25, 2022
★★★★★ 4
Probably Great for Any Normal Creature
Ok to be fair my lab/pit destroys anything he touches, and this kept him occupied for a solid week before he tore it to shreds. He absolutely adored it, chewed it, played keep away and tug of war with it, but like all toys he loved it too hard. Still yet to find something he doesn't decimate and honestly it may not exist, but this certainly withstood more than many a chew toy can claim. If you don't have a wood chipper for a pet, I'd highly recommend.
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Reviewed in the United States on September 1, 2019
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