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Description
Mouse RBP4 Recombinant Rabbit mAb (S-3647)Product Specification Host Rabbit Antigen RBP4 Clone Number S 3647 Antibody Type Recombinant mAb Isotype IgG Application ELISA Reactivity Ms Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20 C as supplied Dilution application dilution species ELISA 1: 5000 1: 10000 Ms
Product Specification
| Host | Rabbit |
| Antigen | RBP4 |
| Clone Number | S-3647 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | ELISA |
| Reactivity | Ms |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| ELISA | 1:5000-1:10000 | Ms |
Background
Mouse RBP4 (Retinol-Binding Protein 4) is a 21-kDa lipocalin-family protein featuring a conserved β-barrel structure that encapsulates all-trans retinol within its hydrophobic core. It mediates systemic vitamin A transport by forming a stabilizing complex with transthyretin (TTR), thereby extending its plasma half-life and preventing renal clearance. The mouse ortholog shares >90% sequence identity with human RBP4, including critical retinol-binding residues (e.g., Leu39, Phe61), but exhibits distinct kinetics in TTR binding compared to rat and human variants. Functionally, RBP4 ensures retinoid delivery to peripheral tissues, supporting vision, embryogenesis, and epithelial maintenance. Emerging evidence implicates mouse RBP4 as a modulator of glucose metabolism, with transgenic studies demonstrating its causative role in insulin resistance. Its dual roles in retinoid signaling and metabolic regulation make it a compelling therapeutic target for metabolic syndrome and ocular diseases in preclinical models.
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4.3 ★★★★★
Based on 160 reviews
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Product Reviews
★★★★★ 5
Reading this book was an enlightening experience for me.
Format: Kindle
The Alchemist by Paulo Coelho provided hours of magical reading. It isn’t a plot-driven book, but rather a novel that provides a quiet sense of purpose and a deeper understanding of the universe. The period the story takes place isn’t clear, but it begins in Spain.
Santiago, a young man, perhaps in his teens, studied to be a priest, but realized what he really wanted to do was to be a shepherd, to move around, see new places. With the blessings of his family, he sets out with his flock of sheep and discovers not only the world, but himself. It soon becomes clear that what he searches for is an alchemist, a person who transforms things for the better.
Santiago meets people along the way who teach him many truths, some good, some evil, but each experience leads him closer to life’s true meaning.
This novel has an interesting history. “The Foreword” written by the author in 2014 speaks about the interesting path the novel has taken. The book was first published in 1989 in his native Brazil. Only one person bought a copy the first week of its release, then six months later another copy sold to the same person! His publisher cancelled the contract. Another publisher agreed to take the book and gradually had great success. An American read the book and wanted to translate the book from Spanish to English and find a publisher in the United States. It didn’t happen overnight, but the book became a phenomenon, has been translated into more than eighty different languages, and has sold thousands of copies.
Paulo Coelho never wavered in his faith in the book because it speaks of his own beliefs: A man sets out on a journey seeking a beautiful or magical place and then realizes the treasure lies within himself.
Reading The Alchemist was an enlightening experience for me. I highly recommend it for those who appreciate life’s purpose and who seek wisdom of the universe.
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Reviewed in the United States on October 7, 2025
★★★★★ 3
Good book, but I think the ending is a betrayal
Format: Kindle
As I write this I realize that I am talking about a modern classic, one that I must admit I did enjoy reading overall. But that said, I simply didn’t find this book to be as moving a book as I thought I would.
The novel tells a simple though interesting tale about a boy’s attempts to search for a treasure revealed to him in multiple dreams. Along the way he encounters many people and situations that enable him to learn and grow spiritually, aided by either his clever and inquisitive mind or the guidance of others who effectively serve as mentors.
For the most part, I did like THE ALCHEMIST. I enjoyed the simple style of writing and the stripped-down nature of the tale. We don’t get into the “five senses” kind of environmental description – Coelho’s tale is more of a parable at its heart, and in fact is a story OF the heart and of the mind. I also admired the central character as well: Santiago is not only aptly named, but he is a likable boy full of pleasant good will and a gentle disposition, ready to work and clever when it comes to the things one must do to succeed. He is also brave, and remains positive whether things are going well or they are not, choosing to do the best he can at whatever hand he is dealt by life.
Here, however, comes the problem. While I felt that the book worked for a good deal of the story, it weakened a bit toward the end. Part of it was the story’s mumbo-jumbo manner of religiosity; while I understood the author’s decision to tackle his subject in this simple, unadorned manner, it didn’t hold up at times. Certainly, the notion that there is a hidden one-ness at the heart of all matter is a notion that works well through a simplistic style, a la the clean, stripped-down beliefs at the heart of innocents or the way we conceptualize the purity of, say, the Native Americans culture when it came to nature. But when the boy began addressing the wind and other elements (a point I’ll get to further in a moment), it really broke down for me. It stretched credulity, reducing Nature to a kind of repertory theater. I will speak further on this scene in a second.
HERE I ONE ASPECT THAT WOULD BE CONSIDERED A SPOILER – SKIP THIS PARAGRAPH.
What I particularly disliked about THE ALCHEMIST is that I felt it broke its own rules. Again, I’m discussing the ending here, so beware. It bothered me that the ending should have been a point when the boy’s budding spirituality took its hold upon the lad. I ask: why would a person who is in essence learning so much about what really matters about life still keep seeking money? His interest in gold is not the same as the alchemist’s interest in it: the elder character is a man who can manipulate the elements in a near-magical manner, a process he leaves the boy to discover for himself (like when he fact almost comically abandons him to magically “make like the wind” for men who will otherwise kill him – comical because once the alchemist places the boy IN the situation, he simply goes off to play with his birds. And one more thing: while the twist at the end was clever, it disappointed me for two reasons: the first, for point I made above, but the second is trickier. The boy learns that the truth the material treasure HE sought is NOT there; it is, he learns, where the OTHER character says it is. Clever, sure… but is the author telling us the other character’s “information” is more true? Why is that? Was it that the other boy was favored? OR, which is probably more true, is it because whatever force it is that imparts such “wisdom” does so knowing that one boy WILL follow his heart and the other won’t. Think: if the other boy does follow his quest then Santiago’s info is going to be wrong. But IF things are meant to work out the way they actually do, then is Coelho indeed telling us that these actions were predetermined? This sends, I think, the opposite message the author wants to send.
THE ALCHEMIST is a book that people will enjoy for its simple values, and the tale of this young boy’s spiritual quest has satisfied many. While I too enjoyed it and liked the boy, I ultimately felt a bit disappointed in what I felt to be a contrived ending. Though I initially liked the twist at the end, the story could have ended on that exact moment and left me happier. As it is, I felt the final portion of the boy’s quest betrayed his AND the author’s intentions, which hurt the novel for me.
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Reviewed in the United States on October 4, 2016
★★★★★ 5
Actually get your skin clean rather than smudge with soap and then rinse
Size: Small
PROS
- I use a *lot* less water (including hot water) when showering now because I'm able to soap up with a little water and soap before I start showering.
- Definitely cleaner and healthier skin, feel like I need fewer showers.
- It's been hard to switch back to other types of soap -- this legit feels like the right way to do it.
CONS
- It took a shower or two to get used to the courseness of the pads.
- I have to scrub it against hard soap for a WHILE before it becomes smooth enough to apply enough soap that I can see it.
Overall a win and probably will buy again.
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Reviewed in the United States on March 21, 2026
★★★★★ 5
Love
Size: Large
Love the exfoliating this scrubber offers. They don’t stink or fall apart with continuous use.
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Reviewed in the United States on November 6, 2025
★★★★★ 5
Great condition
Size: Small
Great
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 4, 2025
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