FXR Recombinant Rabbit mAb (S-2845-71)
SKU: 35287299667

FXR Recombinant Rabbit mAb (S-2845-71)

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Description

FXR Recombinant Rabbit mAb (S-2845-71)Product Specification Host Rabbit Antigen FXR Synonyms Bile acid receptor; Farnesoid X activated receptor; Farnesol receptor HRR 1; Nuclear receptor subfamily 1 group H member 4; Retinoid X receptor interacting protein 14 (RXR interacting protein 14); BAR; HRR1; RIP14; NR1H4 Immunogen Synthetic Peptide Location Nucleus Accession Q96RI1 Clone Number S 2845 71 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample 293T,

Product Specification


Host Rabbit
Antigen FXR
Synonyms Bile acid receptor; Farnesoid X-activated receptor; Farnesol receptor HRR-1; Nuclear receptor subfamily 1 group H member 4; Retinoid X receptor-interacting protein 14 (RXR-interacting protein 14); BAR; HRR1; RIP14; NR1H4
Immunogen Synthetic Peptide
Location Nucleus
Accession Q96RI1
Clone Number S-2845-71
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu
Positive Sample 293T, HepG2, MCF7, MDA-MB-231, A431, HeLa, A549, HCT 116
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu

Background

The Farnesoid X receptor (FXR, NR1H4) is a ligand-activated nuclear receptor that functions as the master bile-acid sensor: after binding physiological bile acids such as chenodeoxycholic acid, FXR heterodimerizes with RXR, translocates to DNA FXR-response elements and trans-activates or represses genes that control bile-acid synthesis (CYP7A1), conjugation (BACS, BAAT), export pumps (BSEP, MRP2) and intestinal re-uptake (IBABP, ASBT), while additionally regulating lipid and glucose metabolism, hepatic lipogenesis, energy balance, inflammatory signaling, gut barrier integrity and innate immunity; FXR exists as four human isoforms (α1–α4) and is expressed mainly in liver, intestine and kidney, with synthetic agonists (e.g. GW4064, obeticholic acid) and antagonists under intense investigation for treating cholestasis, NASH, fibrosis, diabetes and intestinal inflammatory disorders.

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Exchange/Return Notes
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SKU: 35287299667

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4.8 ★★★★★
Based on 1713 reviews
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Product Reviews
J
Verified Purchase
Jason Dusterwald
Grantham, US
★★★★★ 4
Fine Simple Product, Works as Advertised
Size: 3-Panel
Performs as advertised, a simple upright divider. I use it to mark my "office" space when working from home. Assembly was straightforward and well documented. One person can do it, but a second person can be helpful when sliding the fabric divider pieces onto their poles. Part quality is fine for the price point. The only mild annoyance is that the upright poles can start getting loose from the metal feet, and need to be retightened occasionally (Allen wrench is included, keep it handy for retightening). It's fairly lightweight and easy to reposition, but the feet are heavy enough to keep it steady once placed. All in all, a good product. I was pleased enough to buy a second one when my son wanted something to block sunlight from behind his computer desk.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 18, 2025
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Verified Purchase
Sheila Cash
Pawtucket, US
★★★★★ 1
Wobbly and Poor Design
Size: 1-Panel
Update: nope! Not worth the money. My cat simply brushed against the divider, and it fell, knocking breakable things over. Not safe! It serves it's purpose, but...the screws were basically glued to the packaging. It took me longer to get the screws out of the packaging than it did to put it together. The assembly was easy. I am not mechanically inclined by any means, but the instructions, despite being very hard to read (I have over 40 eyes), were pretty simple. Structurally, it is very wobbly. I think they should have designed it with a middle rod to keep it more stable. I find that the attachments to the rods are wobbly and should have been screwed rather than popped into an attachment hole without reinforcement. That would have also made the room divider more stable. I have cats, but the material is easy to clean. I took a damp cloth to it, and it came right off. As far as see-through...I think it does a great job of masking theO other side of the room.. I just wish it was a little longer and closer to the floor stand. I like that it came with extra parts. It's just a very cheaply made item, and I don't think the price for the item reflects how cheaply it is made, how wobbly and unstable it is, or the poor design.
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Reviewed in the United States on March 15, 2025
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Verified Purchase
David T Stark
Pawtucket, US
★★★★★ 5
Very good room divider
Size: 6-Panel
I ised this to isolate a storage area in my apartment. Looks better than boxes.
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Reviewed in the United States on January 22, 2026
J
Verified Purchase
Jodie
Lake Worth, US
★★★★★ 3
Taking forever but worth it
Size: 1-Panel, Size: 1-Panel
Love the product. However, trying to take the screws etc out of its box, it’s almost impossible due to the adhesive inside it. I have neck and arm issues so for me it was even more difficult. Adhesive stuck to each washer and screw so I had adhesive all over my hands then I had to get it off of the items.
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Reviewed in the United States on April 21, 2025
O
Verified Purchase
Oulu family
Birmingham, US
★★★★★ 5
Good value for the money.
Color: Black, Size: 6 Panel
This partition package is a great value. I looked at many options and this one had long length to cover an entire room with the six partitions. The pieces went together easily, took about 30 minutes to assemble and has the needed Allen wrench included. It is stable with no fear of being easily knocked down. The black fabric does not completely hide everything and if there is a light on the inside, it can illuminate what is going on. It does the job but if you wanted complete privacy you would need thicker material. Overall it does what I need in that it make a TV room into a kind of guest room of sorts.
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Reviewed in the United States on May 20, 2026

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