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Description
Human Laminin gamma 1, His TagProduct Specification Species Human Synonyms aminin subunit gamma 1, Laminin B2 chain, Laminin 1 subunit gamma, Laminin 10 subunit gamma, Laminin 11 subunit gamma, Laminin 2 subunit gamma, LAMC1 Accession P11047 Amino Acid Sequence Protein sequence(P11047, Gln34 Leu484, with C 10*His)
Product Specification
| Species | Human |
| Synonyms | aminin subunit gamma-1, Laminin B2 chain, Laminin-1 subunit gamma, Laminin-10 subunit gamma, Laminin-11 subunit gamma, Laminin-2 subunit gamma, LAMC1 |
| Accession | P11047 |
| Amino Acid Sequence |
Protein sequence(P11047, Gln34-Leu484, with C-10*His)
|
| Expression System | HEK293 |
| Purity | ＞95% by SDS-PAGE |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage |
12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
Laminins are a family of glycoproteins of the extracellular matrix of all animals. They are major components of the basal lamina (one of the layers of the basement membrane), the protein network foundation for most cells and organs. The laminins are an important and biologically active part of the basal lamina, influencing cell differentiation, migration, and adhesion. Laminins are heterotrimeric proteins with a high molecular mass (~400 to ~900 kDa). They contain three different chains (α, β and γ) encoded by five, four, and three paralogous genes in humans, respectively.The laminin family of glycoproteins is an integral part of the structural scaffolding in almost every tissue of an organism. They are secreted and incorporated into cell-associated extracellular matrices. Laminin is vital for the maintenance and survival of tissues. Defective laminins can cause muscles to form improperly, leading to a form of muscular dystrophy, lethal skin blistering disease (junctional epidermolysis bullosa) and defects of the kidney filter (nephrotic syndrome).
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