Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 8 - Jul 13
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Biotin Rat Anti-Mouse TIM-3 (CD366) Antibody (S-R478)Product Specification Host Rat Antigen TIM 3 (CD366) Synonyms Hepatitis A virus cellular receptor 2 homolog; HAVcr 2; T cell immunoglobulin and mucin domain containing protein 3 (TIMD 3); T cell immunoglobulin mucin receptor 3 (TIM 3); T cell membrane protein 3; Tim3; Timd3; Havcr2 Location Membrane Accession Q8VIM0 Clone Number S R478 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample CD3, CD28 antibody treated C57BL
Product Specification
| Host | Rat |
| Antigen | TIM-3 (CD366) |
| Synonyms | Hepatitis A virus cellular receptor 2 homolog; HAVcr-2; T-cell immunoglobulin and mucin domain-containing protein 3 (TIMD-3); T-cell immunoglobulin mucin receptor 3 (TIM-3); T-cell membrane protein 3; Tim3; Timd3; Havcr2 |
| Location | Membrane |
| Accession | Q8VIM0 |
| Clone Number | S-R478 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | CD3, CD28 antibody treated C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
TIM-3 (CD366) is a trans-membrane immune checkpoint receptor in the Ig super-family whose extracellular domain binds phosphatidyl-serine, CEACAM-1 or galectin-9 ligands to trigger downstream signaling through its conserved cytoplasmic tyrosine motif, thereby attenuating T-cell, NK-cell and dendritic-cell activation while promoting regulatory T-cell function and myeloid tolerance, making its blockade a promising strategy for enhancing anti-tumor and anti-viral immunity across multiple cancers and chronic infections.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy