Human STAT6/CRBN PROTAC Binding Kit
SKU: 97436158317

Human STAT6/CRBN PROTAC Binding Kit

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Description

Human STAT6/CRBN PROTAC Binding KitProduct Specification Stability & Storage Save according to the preservation conditions and it will be valid for one year. Background The kit employs homogeneous time resolved fluorescence resonance energy transfer (TR FRET) technology to measure the interaction between STAT6 and CRBN mediated by the molecular glue AK 1690 and the compounds to be tested. This method enables a simple, rapid, and high throughput detection of small molecules that can

Product Specification


Stability & Storage

Save according to the preservation conditions and it will be valid for one year.

Background

The kit employs homogeneous time-resolved fluorescence resonance energy transfer (TR-FRET) technology to measure the interaction between STAT6 and CRBN mediated by the molecular glue AK-1690 and the compounds to be tested. This method enables a simple, rapid, and high-throughput detection of small molecules that can mediate the interaction between STAT6 and CRBN. As shown, the interaction between STAT6 and CRBN is detected using Eu-labeled anti-Tag1 antibody (TR-FRET donor) and Ac-labeled anti-Tag2 antibody (TR-FRET acceptor). Since the molecular glue AK-1690 mediates the interaction between STAT6 and CRBN, the donor and acceptor antibodies are brought into close proximity. The excitation of the donor antibody triggers fluorescence resonance energy transfer (FRET) to the acceptor antibody, causing the acceptor antibody to specifically emit a signal at a wavelength of 665 nm. This specific signal is proportional to the degree of interaction between AK-1690 and STAT6, CRBN. The homogeneous assay is simple to operate and does not require any washing steps.


Components

Component

Concentration

500 TESTS

2500 TESTS

10000 TESTS

Storage temperature

Tag1-STAT6 protein

50×

40uL

200uL

800uL

-80℃

Tag2- CRBN protein

50×

40uL

200uL

800uL

-80℃

AK-1690 (150uM)

100×

10uL

50uL

200uL

-80℃

Anti-Tag1 Eu antibody

50×

50uL

250uL

1000uL

-80℃

Anti-Tag2 Ac antibody

12.5×

200uL

1000uL

4000uL

-80℃

Detection buffer

5×

2mL

10mL

40mL

-80℃

The reagents should be avoided from repeated freezing and thawing. It is recommended to aliquot them after the first thawing and store them according to the preservation conditions. The validity period is one year.

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SKU: 97436158317

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4.8 ★★★★★
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Lydia Wormsley
Louisville, US
★★★★★ 5
Great book!
Format: Paperback
Wonderful, helpful, insightful. Points out many of the key "sore spots" that can sour a marriage if left unmanaged, and how to address them. Very helpful, whether as a premarital counseling book, a book for the happily married couple, or even for the unhappily married couple willing to set their relationship right. Must read!
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Reviewed in the United States on February 10, 2026
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MISTY C.
Belleville, US
★★★★★ 5
Great buy
Format: Paperback
Good read.
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Reviewed in the United States on May 28, 2026
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Jenna H
Natrona Heights, US
★★★★★ 4
Good discussion book to eliminate conflict between couples
Format: Kindle
Use this book as a checklist of things you should discuss with your partner - especially if you're considering or are in a long-term relationship. It explains each topic, why it's a likely source of conflict, how to prevent the conflicts, and includes questions for discussion between partners. Understanding and discussing these topics may not feel romantic and fun, and some of the conversations may be challenging for couples who aren't accustomed to such discussions. Do it anyway though because it will eliminate future conflicts before the conflicts even begin and make your relationship run smoother, last longer, and be a source of relaxation and contentment for you both. I'm speaking from experience here. If you are new to the study of this topic, this book will be extremely valuable for you. If you've already studied interpersonal relationships, preemptive conflict resolution, and collaborative negotiation tactics, it's still a great checklist of topics to discuss with your partner. I'm on this end of the spectrum, hence 4 of 5 stars because I'm familiar with the author's other work and this book didn't contain much new content. As a compact, all-in-one, relationship discussion guide though, it's great and worth reading and having on hand for future reference for new relationships or for when new conflicts crop up.
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Reviewed in the United States on March 3, 2018
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Johanna
Houston, US
★★★★★ 5
Easy to read
Format: Paperback
Very interesting book!
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Reviewed in the United States on April 20, 2026
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Susan
Pawtucket, US
★★★★★ 5
Great for Everyone!
Format: Paperback
This book is very useful to prepare people for marriage and I would recommend it for teens (even if they're not in a relationship), engaged couples, and even those already married since this provides realistic information about love and that not everything in a relationship is easy. It also helps people understand and attempt to loosely preset chores around the house and understand what to do with the extra money earned that isn't needed for bills. While I was already aware and have read about the 5 love languages, that is only briefly covered in one chapter while the rest provides other information so if you already read the 5 Love Languages book understand that there is a lot more involved in this book than that concept. The concept that I want to highlight in this book that I haven't read about before was the 5 Different Ways to Apologize. Increasingly, I think people need to be aware that what we consider to be a 'sincere apology' isn't necessarily the same as everyone else's though there are 5 of them that are fairly common. I was surprised when I found what I thought to be a sincere apology was listed word-for-word! This concept alone can be applied to anyone you socialize with and I especially recommend this piece if you are having apology problems between your friend, significant other, coworkers, and/or boss. Teens and those single will be able to learn a lot from this book, especially to realize that people, on average, are no longer "falling in love" within two years of the relationship and I think this would help them understand that relationships take a lot of work even when it's not convenient for you. Giving them an understanding of how to be flexible when apologizing and to know that people feel loved according to different love languages will make them more aware of how to improve their friendships and relationships in the future. Finally, there is reinforcement in being willing to do chores even if they're not popular and generally establishing healthy spending habits. I personally found this book to be thrilling and Gary Chapman successfully backs up some of his findings with Psychological research and definitions. I loved it so much that I read it in one sitting and now I'm getting my teen friends and budding couples into reading it. Awesome book; give it a try if you haven't already! (:
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Reviewed in the United States on June 30, 2016

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