SKU: 87097093269

Hista Clear - DAO Enzyme (60 tablets)

Sale price$57.60 Regular price$64.00
Save 10%

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Jul 14 - Jul 19

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

Hista Clear - DAO Enzyme (60 tablets)NEW: Now in NEW packaging Conners Clinic Originals Hista Clear is a patented enzyme formula containing diamine oxidase (DAO) the main enzyme responsible for the degradation of ingested histamine. This enzyme has been clinically tested and found to break down food derived histamine in the digestive tract. Our bodies are complex, and there is usually more at play than we think. What most dont take into consideration when addressing histamine related

NEW: Now in NEW packaging

Conners Clinic Originals Hista Clear is a patented enzyme formula containing diamine oxidase (DAO) - the main enzyme responsible for the degradation of ingested histamine.  This enzyme has been clinically tested and found to break down food-derived histamine in the digestive tract.  

Our bodies are complex, and there is usually more at play than we think. What most don’t take into consideration when addressing histamine-related health issues is genetics. Whether you’re on a low histamine diet due to histamine intolerance, or simply trying to reduce high histamine foods for general health, you will benefit from understanding how your genes are related. Learn more about histamine and genetics here!

Our body has two distinct methods of clearing things that could bring it harm: our immune system kills living toxins (bacteria, virus, parasites…) and our detoxification pathways clear non-living toxins (chemicals, heavy metals, drugs…). We have one other system that sits somewhere in the middle between the immune and the detoxification systems that helps with both: the mast cells. Read more about Histamine’s Double-edge Sword in the Formation and Progression of Cancer.

 

Clinical Applications
  • Supports Healthy Degradation of Food-Derived Histamine*
  • Enhances the Presence of Diamine Oxidase in the Digestive Tract*
Description:


Hista Clear provides a concentrated source of diamine oxidase (DAO)—the main enzyme responsible for the degradation of ingested histamine. This formula delivers the clinically researched dose of DAO in an easy-to-swallow, gastro-resistant mini-tablet, which is essential for releasing DAO in the small intestine, where it breaks down food-derived histamine. HistDAO does not manage or address antibody-related or IgE-related food allergies.*

Discussion:

Histamine is a bioactive or “vasoactive” amine produced in the body in response to an injury or foreign substance. It has an array of physiological effects, including increasing blood supply to specific sites in the body. In addition, histamine is involved in the immune response, regulation of gastric acid, permeability of blood vessels, contraction of muscles, and the normal response to inflammation.[1] The highest concentrations of histamine in the body are found in the gastrointestinal tract, lungs, and skin, with lesser amounts in the brain and heart.*

Histamine is not only produced in the body but is also present in many fermented foods, such as sauerkraut, sausage, cheese, yogurt, and alcoholic beverages. Tuna, olives, spinach, eggplant, avocados, tomatoes, cherries, and citrus fruits are other histamine-containing foods. Despite their absence of histamine, some foods, such as berries, tea, and a variety of spices, stimulate the endogenous production of the amine due to their benzoate content. In addition, microbial fermentation can convert the histidine in high-protein foods to histamine so that the histamine content of food can increase over time.*[1]

Endogenous and exogenous histamine must be broken down in order to maintain homeostasis and histamine balance. The enzyme diamine oxidase (DAO) degrades histamine by converting it from 2-(4-imidazolyl)- ethylamine to the inactive metabolite imidazole acetaldehyde.[2] The active ingredient in HistaClear is porcine-derived diamine oxidase, and research suggests that DAO derived from porcine kidney appears to have identical action to DAO derived from porcine intestine.[3] In humans and other mammals, DAO is found in high concentrations in the gastrointestinal mucosa. Animal studies suggest that circulating DAO may be a marker for mucosal integrity and maturity.[4] Certain drugs may affect histamine balance in the body by promoting histamine release or inhibiting DAO.*[2]

Histamine tolerance may not be the same for everyone. Results of a double-blind, placebo-controlled crossover study suggest that tolerance to histamine can vary from individual to individual.[5] Total body histamine load must be considered when evaluating histamine tolerance, and a balance between histamine and DAO appears to be crucial to maintaining skin, rhinoconjunctival, and gastrointestinal health.[2,6] Genetic and environmental factors may interact to influence DAO expression. Ongoing research addresses the role that genetic variations may play in individual differences in DAO metabolism, and serum activity was significantly associated with seven single nucleotide variations within the DAO gene.[7,8] Histamine tolerance may be reflected in detailed questionnaires, food intake logs, trial with low-histamine diet, and measurement of DAO and histamine.*[9,10]

Histamine tolerance and its manifestation may vary from organ to organ as well. A study of 39 patients suggested that intake of DAO produced a statistically significant reduction in symptoms associated with exogenous histamine ingestion, although single symptoms were not found to be reproducible.*[11]

Ultimately, diminished serum DAO levels appear to be associated with changes in histamine degradation and serum histamine levels.[10] Although the mechanism of histamine degradation is uniform throughout the body, HistaClear only addresses excess exogenous histamine found in the folds, villi, and microvilli of the small intestine. HistaClear is not absorbed and therefore does not have systemic activity. A two-capsule dose of HistaClear contains 20 mg of vitamin C and 20,000 HDU (histamine degrading units) from diamine oxidase. HistaClear is NOT EFFECTIVE for symptoms of immune- related food allergies, such as peanuts, shellfish, etc.*

Read our article: Low Histamine Diet: The High Histamine Foods List

Genetic supplementation is complex and requires a deep understanding of the entire genetic picture.  Our Genetics Membership includes the kit, a full workup, review, report, summary, Dr. Conners’ personalized recommendations - and MORE.  Click HERE for details.

Video:


Directions:

Take 1-2 capsules no more than 15 minutes before the consumption of histamine-rich foods, or take as directed by your healthcare practitioner.

Cautions:

Consult your healthcare practitioner before use, especially if you are pregnant or nursing. Keep out of reach of children. Avoid if allergic to pork or any other ingredient. HistaClear is NOT EFFECTIVE for symptoms of immune- related food allergies, such as peanuts, shellfish, etc.


Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 87097093269

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.3 ★★★★★
Based on 1754 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
T
Verified Purchase
Talbot Hackett
Draper, US
★★★★★ 5
Excellent machine
Style: WF-3820 (Renewed)
I first bought this printer on Feb 6. When it arrived, I could not set it up due to a maintenance box error. I contacted Epson and received a replacement within 2 days. I still got a maintenance Box error, so I contacted Amazon for a replacement printer. The new printer arrived today and the set-up my internet and Chromebook went very smoothly. I have used Epson printers for nearly 20 years and have been very satisfied, so I took a chance on a refurbished to save a few dollars. I was not disappointed. Epson service was excellent and Amazon's hassle-free return policy makes everything very easy. New or refurbished, I will go with Epson every time. Customer service goes a long way with me.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 26, 2024
L
Verified Purchase
LB Guy
Lexington, US
★★★★★ 5
Clear printing
Style: WF-3820 (Renewed)
Make good, clear prints and copies. The printer is on thelarge side.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 24, 2023
R
Verified Purchase
Raz
Los Angeles, US
★★★★★ 5
Like new in every way
Style: WF-3820 (Renewed)
Nice printer overall, wi-fi setup went fairly smooth Windows 11, printer wi-fi smooth, Windows took a couple times before finding. If I did tones of printing, price of ink would be a huge deterrent!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 16, 2023
K
Verified Purchase
Kindle Customer
Draper, US
★★★★★ 4
ok design
Style: WF-3820 (Renewed)
good basic at home printer. really like the wireless feature
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 3, 2023
S
Verified Purchase
Serina Anthony
Charlottesville, US
★★★★★ 1
Do not buy Epson if you expect it to last.
Style: WF-3820 (Renewed)
I had previously had HP printers and they worked extremely well, honestly I had them for years and years at a time, much longer than would probably be typical for an at-home printer that gets a lot of use. I bought an Epson replacement as the price was right. I replaced the ink once in it, and it worked fine...then it would never read new ink. Well, it would read it was full, but it would print extremely light and if you had a barcode (like to return an Amazon package) the barcode would not print correctly to be able to use for shipment. So, I thought I must have just gotten a bad printer and that it was a year old so I guess it was due...so I bought this one. I have had it since May and just replaced the black in - and it is now doing the SAME thing as the previous Epson. It will not print correctly. I called Espon support and was told they could send me a new one BUT I had to give a CC# for them to 'hold' and it would not be charged if I returned the item. Well, then once it got down to it, she then stated that when the new one was sent back, they would 'review to make sure it is covered under warranty' and that it is 'their property' then, and if it is not under warranty, I would be charged...which was TWICE what I paid for the printer originally. So I told her nevermind. She could not understand why, which they state some arbitrary statement that 'if' it is found to be 'under warranty' then I would not be charged, but also specifying once returned it is their property. So, basically that sounded too 'iffy' to me and I am not going to return something to MAYBE not get charged DOUBLE what I paid for the item to begin with. That seems like a scam to get paid for the replacement item to be honest.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 11, 2023

recommand products