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Description
ADAMTS14 Recombinant Rabbit mAb (S-2935-69)Product Specification Host Rabbit Antigen ADAMTS14 Synonyms A disintegrin and metalloproteinase with thrombospondin motifs 14; ADAM TS 14; ADAM TS14; ADAMTS 14 Immunogen Synthetic Peptide Location Secreted Accession Q8WXS8 Clone Number S 2935 69 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0.
Product Specification
| Host | Rabbit |
| Antigen | ADAMTS14 |
| Synonyms | A disintegrin and metalloproteinase with thrombospondin motifs 14; ADAM-TS 14; ADAM-TS14; ADAMTS-14 |
| Immunogen | Synthetic Peptide |
| Location | Secreted |
| Accession | Q8WXS8 |
| Clone Number | S-2935-69 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
ADAMTS14 is a secreted 1223-amino-acid member of the ADAMTS zinc metalloproteinase family that processes extracellular matrix components, displaying the signature architecture of a signal peptide, prodomain, peptidase M12B catalytic domain, disintegrin-like module, cysteine-rich spacer and four thrombospondin type-1 repeats followed by a PLAC domain; it is expressed in placenta, retina, lung and brain, cleaves the N-terminal propeptide of type I procollagen to facilitate collagen fibril formation, modulates TGF-β signaling and mesenchymal cell behavior, and genetically or expressionally altered ADAMTS14 has been linked to osteoarthritis, intervertebral disc degeneration, cancer progression, cardiovascular remodeling and pulmonary fibrosis.
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